Albert Hofmann

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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Extract: This paper reports the cytogenetic investigation of nine children exposed to LSD in utero , four children of other LSD users not exposed in utero , the mothers of these children, and six additional adults taking the drug.

In comparison with matched controls, significantly elevated frequencies of chromosomal damage were observed in all the individuals exposed. The frequencies of aberrations, however, were markedly reduced in those children not exposed in utero. Eight structural rearrangements were observed, six dicentric chromosomes and two quadriradial formations, among those individuals exposed to the drug, but none was observed in the controls.

In spite of obvious chromosomal aberrations, all of the individuals in this study were apparently healthy and showed no obvious birth defects.

The Effect of LSD-25 on the Chromosomes of Children Exposed in Utero

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. All modern clinical studies using the classic hallucinogen lysergic acid diethylamide LSD in healthy subjects or patients in the last 25 years are reviewed herein.

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About LSD including other names for the drug, short-term and long-term mental and Answer a few questions to see if you qualify to take part in a research session, at a date and time convenient to you On this page.

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Albert Hofmann 11 January — 29 April [1] [2] was a Swiss chemist known best for being the first known person to synthesize , ingest , and learn of the psychedelic effects of lysergic acid diethylamide LSD. Hofmann was also the first person to isolate, synthesize, and name the principal psychedelic mushroom compounds psilocybin and psilocin. Hofmann was born in Baden, Switzerland , the first of four children to factory toolmaker Adolf Hofmann and his wife Elisabeth born Elisabeth Schenk.

Owing to his father’s low income, Albert’s godfather paid for his education. When his father became ill, Hofmann obtained a position as a commercial apprentice in concurrence with his studies.

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Tuppurainen and K.

The psychedelic drug (or entheogen) lysergic acid diethylamide (LSD) was first synthesized on accidental exposure on April 16, but that date fell midweek and was not a good time for the party, so he chose the Page 1: The Desert Sun. p.

LSD is a potent hallucinogenic drug. It is made from lysergic acid, which is found in a fungus that grows on rye and other grains. LSD can have long-lasting impacts on your brain and emotional state. This is true even if you use the drug only once. LSD stands for lysergic acid diethylamide. It causes hallucinations and has very unpredictable effects.

In its pure form LSD is a white, odourless and slightly bitter crystalline powder. On the street it is often sold as small squares of LSD-soaked blotting absorbent paper. These squares each contain 1 dose of LSD and are taken by mouth. It is generally held on the tongue or swallowed.

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The psychedelic drug or entheogen lysergic acid diethylamide LSD was first synthesized on November 16, by the Swiss chemist Albert Hofmann in the Sandoz now Novartis laboratories in Basel, Switzerland. Albert Hofmann, born in Switzerland, joined the pharmaceutical-chemical department of Sandoz Laboratories, located in Basel , as a co-worker with professor Arthur Stoll, founder and director of the pharmaceutical department.

His main contribution was to elucidate the chemical structure of the common nucleus of Scilla glycosides an active principle of Mediterranean Squill. It was set aside for five years, until April 16, , when Hofmann decided to take a second look at it. While re-synthesizing LSD, he accidentally absorbed a small amount of the drug and discovered its powerful effects. At home I lay down and sank into a not unpleasant intoxicated-like condition, characterized by an extremely stimulated imagination.

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In this paper our aim is to examine whether research conducted on human participants with LSD lysergic acid diethylamide raises unique research ethical questions or demands particular concerns with regard to the design, conduct and follow-up of these studies, and should this be the case, explore and describe those issues. Our analysis is based on reviewing publications up to date which examine the clinical, research and other uses of LSD and those addressing ethical and methodological concerns of these applications, just as some historical examinations of this subject.

The first chapters of the paper give an overview regarding the history of LSD-research with human participants, healthy volunteers and patients alike. The remaining chapters have a focus on questions regarding the potential ethical issues of such human trials in the contemporary research ethics framework. We also consider briefly political and regulatory issues regarding this substance that possibly affect its clinical and research applications.

For example, in alone more than 10 experiments were reported that involved LSD administered to human subjects. At the same time, however, there has been little reflection on the research ethics issues involved in this subject. In this paper we examine whether research conducted on human participants with LSD raises unique research ethics questions. In what sense do these studies demand particular attention with regard to the design, conduct and follow-up of these studies and what kind of special research ethics issues must be considered?

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